Journal: Pharmacoepidemiology and Drug Safety
Authors: Susan S Jick, Katrina Wilcox Hagberg, Rebecca Persson, Catherine Vasilakis-Scaramozza, Tim Williams, Elizabeth Crellin, Puja Myles
NLM Citation: Jick SS, Hagberg KW, Persson R, Vasilakis-Scaramozza C, Williams T, Crellin E, Myles P. Quality and completeness of diagnoses recorded in the new CPRD Aurum database: evaluation of pulmonary embolism. Pharmacoepidemiol Drug Saf. 2020 Sep;29(9):1134-1140. doi: 10.1002/pds.4996. Epub 2020 Mar 28. PMID: 32222005.
Abstract
Purpose: The Clinical Practice Research Datalink (CPRD) now provides a new medical record database, CPRD Aurum. This is the first of several studies being undertaken to assess the quality and completeness of CPRD Aurum data for research endeavors.
Methods: We identified patients with a pulmonary embolism (PE) diagnosis from a random sample of 50 000 patients in CPRD Aurum and compared the diagnoses using data from Hospital Episode Statistics (HES). We calculated the proportion of PE cases recorded in CPRD Aurum who also had a PE diagnosis recorded in HES. We also evaluated completeness by identifying all PE diagnoses in HES and calculating the proportion also present in CPRD Aurum.
Results: The study included 781 PE patients: 580 had a PE in CPRD Aurum, 632 had a PE in HES, and 431 had a PE in both. The proportion of patients with anticoagulated PE in CPRD Aurum confirmed by HES was 76.8%. The completeness of primary hospitalized PE HES events compared to CPRD Aurum was 79.1%. In most instances, there was a plausible explanation for the presence of a PE in only one of the two data sources.
Conclusions: The results of this study are reassuring and suggest that the correctness (eg, quality, accuracy) and completeness of diagnosis information in CPRD Aurum are promising with respect to serious acute conditions that require medical attention. Evaluation of other data elements will provide additional insight into this new data resource and its utility for medical research.
Keywords: CPRD Aurum; Clinical Practice Research Datalink; data completeness; data quality; data validation; pharmacoepidemiology.
© 2020 John Wiley & Sons Ltd.
